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For research and educational purposes only. Not intended for human consumption.

Thymulin

Limited Research
Updated Dec 2025

Zinc-Dependent Thymic Nonapeptide | Immune Modulation & Anti-Inflammatory

InjectableNasal
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1-10mcg
1-2x daily
Injectable
Subcutaneous or intranasal
Variable
Typical duration
2-8°C
Refrigerated

Overview

What is Thymulin?

Thymulin (formerly FTS - Facteur Thymique Sérique) is a zinc-dependent nonapeptide hormone produced by thymic epithelial cells. It plays crucial roles in T-cell differentiation, immune modulation, and has anti-inflammatory properties. Thymulin levels decline with age and zinc deficiency, contributing to immunosenescence. Replacement therapy may help restore thymic function.

Key Benefits

T-cell differentiation support, NK cell enhancement, cytokine modulation, NF-κB inhibition, anti-inflammatory effects, thymic function restoration.

Mechanism of Action

Thymulin binds to high-affinity receptors on T-cells and other immune cells, promoting T-cell differentiation and maturation. It modulates cytokine production, inhibits NF-κB signaling, and requires zinc for biological activity.

Molecular Information

857.9 Da (without zinc)
Weight
9
amino acids
Metallopeptide hormone
Type
Amino Acid Sequence:
Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
* Requires zinc (Zn²⁺) binding for biological activity. N-terminal pyroglutamic acid.

Pharmacokinetics

Peak
1-2 hours
Half-life
Short (minutes)
Cleared
~1-2 hours
100%50%0%0h6h12h18h24h
Peak
Half-life
Cleared
Research data

Research Indications

T-Cell Differentiation

Promotes maturation and differentiation of T-lymphocytes in the thymus.

NK Cell Enhancement

Increases natural killer cell activity and immune surveillance.

Cytokine Modulation

Regulates pro- and anti-inflammatory cytokine production.

Research Protocols

Disclaimer: Thymulin is a research compound with limited human clinical data. Protocols are based on animal research and theoretical considerations.

GoalDoseFrequencyRoute
Immune Support1-5mcgOnce dailySubcutaneous or intranasal
Anti-Inflammatory5-10mcg1-2x dailySubcutaneous
Thymic Restoration1-10mcgDailySubcutaneous

Timing: Morning administration may align better with natural hormone rhythms.

Peptide Interactions

How to Reconstitute

Important: Always use bacteriostatic water (BAC). Sterile technique is essential.

1

Clean vial top with alcohol swab

2

Add bacteriostatic water slowly to lyophilized powder

3

Gently swirl - do not shake

4

Solution should be clear

5

Ensure zinc is present (either in formulation or supplemented)

6

Store reconstituted solution refrigerated

7

Use within 14 days

Dosing Calculator

Calculate your injection volume with visual dosing guide

FINAL CONCENTRATION
2.50mg/mL
Each milliliter contains 2.50 mg of peptide
VISUAL REFERENCE (RESEARCH USE ONLY)

To obtain 250 mcg from this solution:

Draw 0.10 mL=10 units

(1 mL = 100 units on any insulin syringe)

0102030405060708090100
00.10.20.30.40.50.60.70.80.91.0
0.10 mL
10 units

Draw to this mark for 250 mcg

This calculator is for research purposes only. Always verify calculations and consult protocols.

Quality Indicators

Zinc-complexed form

Active form requires zinc binding.

Clear solution

Should be clear and colorless when reconstituted.

Zinc requirement

Inactive without adequate zinc - ensure status.

Cloudy solution

Indicates degradation or contamination.

What to Expect

  • Week 1-2: Minimal noticeable effects
  • Week 2-4: Some may notice improved immune function
  • Week 4-8: Anti-inflammatory effects may become apparent
  • Effects depend heavily on zinc status and baseline immune function

Side Effects & Safety

Side Effects

  • Generally well-tolerated in research settings
  • Limited human safety data available
  • Requires adequate zinc for activity
  • Theoretical risk of immune overstimulation in autoimmune conditions
  • Not recommended during pregnancy

When to Stop

  • Signs of autoimmune activation
  • Allergic reactions
  • Adverse immune effects
  • As directed by healthcare provider

References

2 Studies

Thymulin Anti-Inflammatory Effects

Animal | Various models | NF-κB inhibition, pain relief

Demonstrated anti-inflammatory and analgesic properties through NF-κB pathway modulation.

Age-Related Thymulin Decline

Human | Observational | Significant decline with age

Established that serum thymulin levels decline progressively with aging, contributing to immunosenescence.

Quick Start Guide

Typical Dose
1-10mcg
How Often
1-2x daily
Where to Inject
Subcutaneous or intranasal
Timing
Morning administration may be optimal
Effects Timeline
Immune effects: 2-4 weeks; Anti-inflammatory: 1-2 weeks
Storage
Refrigerate 2-8°C, use within 14 days of reconstitution
Cycle Length
Variable - 4-8 weeks typical
Break Between
2-4 weeks between cycles

Research Disclaimer

Thymulin is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving Thymulin must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of Thymulin for any purpose. Consult qualified professionals for any research applications.