For research and educational purposes only. Not intended for human consumption.
Tesofensine
Well Researched- •12.8% weight loss in Phase 2
- •Triple reuptake inhibitor mechanism
- •Thermogenesis enhancement data
Triple Monoamine Reuptake Inhibitor | Weight Loss
Overview
What is Tesofensine?
Tesofensine is a triple monoamine reuptake inhibitor that blocks the reuptake of norepinephrine, dopamine, and serotonin. Originally developed for Parkinson's and Alzheimer's, it was repurposed for obesity treatment after showing significant weight loss effects. Phase 2 trials demonstrated up to 12.8% weight loss, making it one of the most effective oral weight loss agents studied.
Key Benefits
Significant weight loss (up to 12.8%), appetite suppression, increased energy expenditure, improved lipid profiles, once-daily oral dosing.
Mechanism of Action
Tesofensine inhibits the reuptake of norepinephrine, dopamine, and serotonin in the hypothalamus, reducing appetite and increasing satiety. It also increases thermogenesis and resting energy expenditure.
Molecular Information
Pharmacokinetics
Research Indications
Significant Weight Reduction
Up to 12.8% weight loss at 0.5mg in 24-week Phase 2 trials.
Appetite Suppression
Centrally-acting appetite suppressant with potent effects.
Increased Energy Expenditure
Boosts resting metabolic rate contributing to weight loss.
Research Protocols
Disclaimer: Tesofensine is not FDA approved. It has completed Phase 2 trials but development has been limited by cardiovascular concerns.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Weight Loss | 0.25-0.5mg | Once daily | Oral |
| Starting Dose | 0.25mg | Once daily for 2 weeks | Oral |
| Maintenance | 0.5mg | Once daily | Oral |
Timing: Take in the morning to avoid potential sleep disturbance due to stimulant effects.
Peptide Interactions
How to Reconstitute
Important: Always use bacteriostatic water (BAC). Sterile technique is essential.
No reconstitution needed - oral capsule
Take in the morning with or without food
Swallow whole with water
Do not exceed recommended dose
Store at room temperature
Dosing Calculator
Calculate your injection volume with visual dosing guide
To obtain 250 mcg from this solution:
Draw 0.10 mL=10 units
(1 mL = 100 units on any insulin syringe)
Draw to this mark for 250 mcg
This calculator is for research purposes only. Always verify calculations and consult protocols.
Quality Indicators
High efficacy
One of the most effective oral weight loss agents in trials.
Cardiovascular concerns
Small increases in heart rate and blood pressure observed.
Not FDA approved
Development limited by safety concerns.
CNS side effects
Dry mouth, insomnia, constipation common.
What to Expect
- •Week 1-2: Appetite suppression begins, possible stimulant effects
- •Week 4-8: Significant weight loss (4-8%)
- •Week 12-24: Maximum weight loss achieved (up to 12.8%)
- •Long half-life means effects persist for weeks after stopping
Side Effects & Safety
Side Effects
- •Dry mouth (most common)
- •Insomnia or sleep disturbance
- •Constipation
- •Small increases in heart rate (5-8 bpm) and blood pressure
- •Headache, dizziness
- •Contraindicated in uncontrolled hypertension, cardiovascular disease
- •Not recommended with MAO inhibitors
When to Stop
- •Significant cardiovascular effects
- •Severe insomnia
- •Psychiatric symptoms
- •Uncontrolled blood pressure
- •As directed by healthcare provider
References
2 StudiesPhase 2 Obesity Trial (24 weeks)
Human | 0.25, 0.5, 1.0mg daily | 24 weeks | 10.6-12.8% weight loss
Demonstrated dose-dependent weight loss with 0.5mg showing optimal benefit-risk ratio.
Energy Expenditure Study
Human | Metabolic analysis | 6% increase in resting energy expenditure
Showed tesofensine increases thermogenesis contributing to weight loss.
Quick Start Guide
Research Disclaimer
Tesofensine is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving Tesofensine must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of Tesofensine for any purpose. Consult qualified professionals for any research applications.