For research and educational purposes only. Not intended for human consumption.
KPV
Limited Research- •IBD and gut inflammation research updates
- •NF-κB pathway inhibition mechanism studies
- •Oral and topical bioavailability research
Anti-Inflammatory Tripeptide | Alpha-MSH Fragment
Overview
What is KPV?
KPV is a potent anti-inflammatory tripeptide derived from the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH). This small but powerful peptide exhibits remarkable anti-inflammatory and antimicrobial properties without the pigmentation effects of full α-MSH. KPV has shown particular promise for inflammatory bowel diseases, skin conditions, and immune modulation.
Key Benefits
Systemic anti-inflammatory effects, immune modulation, potential for autoimmune conditions, no pigmentation effects.
Mechanism of Action
Enters cells and inhibits inflammatory pathways at the nuclear level, particularly NF-κB signaling. Reduces circulating inflammatory markers like TNF-α and IL-6.
Molecular Information
Pharmacokinetics
Research Indications
Systemic Inflammation
Reduces circulating inflammatory markers like TNF-α and IL-6.
Autoimmune Modulation
May help balance overactive immune responses.
Joint Inflammation
Potential benefits for inflammatory arthritis.
Research Protocols
Disclaimer: KPV is a research peptide. These protocols are based on available research. Consult a healthcare provider before use.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| General Anti-Inflammatory | 200-300mcg | Once daily | Subcutaneous |
| Active Inflammation | 250mcg | Twice daily | Subcutaneous |
| Autoimmune Support | 500mcg | Once daily | Subcutaneous |
| Acute Flare-ups | 500mcg | Twice daily for 1 week then reduce | Subcutaneous |
Timing: KPV can be dosed flexibly. For gut issues, some prefer morning dosing. For systemic inflammation, split doses may provide better coverage.
Peptide Interactions
How to Reconstitute
Important: Always use bacteriostatic water (BAC). Sterile technique is essential.
Clean vial top with alcohol pad
Add 1mL bacteriostatic water to 1mg vial (creates 1000mcg/mL)
For easier dosing: Add 2mL to 1mg vial (creates 500mcg/mL)
Gently swirl to mix - KPV dissolves easily
Solution should be clear and colorless
Label with concentration and date
Dosing Calculator
Calculate your injection volume with visual dosing guide
To obtain 250 mcg from this solution:
Draw 0.10 mL=10 units
(1 mL = 100 units on any insulin syringe)
Draw to this mark for 250 mcg
This calculator is for research purposes only. Always verify calculations and consult protocols.
Quality Indicators
High Purity Essential
KPV should be >98% pure due to its use in inflammatory conditions.
Clear Solution
Properly dissolved KPV is completely clear and colorless.
Stable Peptide
Small size makes KPV relatively stable compared to larger peptides.
Proper pH
Solution should be pH 5.5-7 for optimal stability.
Visible Particles
Any cloudiness or particles indicate contamination.
Yellow Coloration
Yellowing indicates oxidation and loss of potency.
What to Expect
- •Day 1-3: Subtle reduction in inflammation, improved energy
- •Week 1: Noticeable decrease in inflammatory symptoms
- •Week 2-3: Improved gut function, reduced pain/swelling
- •Week 4: Significant improvement in target condition
- •Week 6-8: Sustained anti-inflammatory benefits
Side Effects & Safety
Side Effects
- •Excellent safety profile with minimal side effects
- •Does not cause immunosuppression like steroids
- •No melanin production or tanning effects
- •May temporarily reduce inflammation-related symptoms
- •Monitor for signs of infection (rare)
- •Generally well-tolerated even at higher doses
When to Stop
- •Signs of infection
- •Allergic reactions
- •Unexpected symptoms
- •As directed by physician
- •After achieving therapeutic goals
References
3 StudiesAntimicrobial Properties Against Gut Pathogens (2022)
In vitro | Multiple bacterial strains | MIC determination | Selective antimicrobial activity
KPV showed selective antimicrobial activity against pathogenic bacteria while preserving beneficial gut microbiota.
KPV for Psoriasis and Dermatitis (2021)
Human cells + Animal model | Topical | 4 weeks | 60% reduction in psoriatic markers
Topical KPV reduced psoriatic markers by 60% and improved skin barrier function.
Anti-Inflammatory Mechanisms (2020)
In vitro | Various concentrations | Cell culture | NF-κB pathway inhibition
KPV enters cells and directly inhibits NF-κB pathway, reducing TNF-α, IL-6, and other inflammatory cytokines.
Quick Start Guide
Research Disclaimer
KPV is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving KPV must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of KPV for any purpose. Consult qualified professionals for any research applications.