For research and educational purposes only. Not intended for human consumption.
Glutathione
Well Researched- •Master antioxidant mechanisms detailed
- •Phase II detoxification pathways
- •Vitamin C/E recycling confirmed
Master Antioxidant | Tripeptide | GSH
Overview
What is Glutathione?
Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine, often called the body's 'master antioxidant.' Found in virtually every cell, it plays critical roles in neutralizing free radicals, detoxifying harmful substances, recycling other antioxidants (vitamins C and E), and supporting immune function. Injectable forms bypass poor oral bioavailability.
Key Benefits
Direct delivery bypasses poor oral bioavailability, rapidly increases plasma glutathione levels, supports detoxification and immune function.
Mechanism of Action
Glutathione directly neutralizes reactive oxygen species via its sulfhydryl group, conjugates toxins for excretion (Phase II detoxification), recycles vitamins C and E, and supports optimal lymphocyte function.
Molecular Information
Pharmacokinetics
Research Indications
Master Antioxidant Function
Primary intracellular antioxidant that neutralizes free radicals and reactive oxygen species.
Antioxidant Recycling
Regenerates oxidized vitamins C and E back to active forms.
Redox Balance
Maintains optimal GSH/GSSG ratio for cellular health.
Research Protocols
Disclaimer: IV administration should be performed by healthcare professionals. Individual responses vary significantly.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| General Antioxidant | 200-400mg | 1-2x weekly | IM or IV push |
| Detoxification | 400-600mg | 2-3x weekly | IV push or infusion |
| Immune Support | 400-600mg | 1-2x weekly | IV or IM |
| Neurological (Parkinson's) | 1400mg | 3x weekly | IV infusion |
| Maintenance | 200mg | 1x weekly | IM or SubQ |
Timing: No specific timing required. IV infusions typically given in clinical settings.
Peptide Interactions
How to Reconstitute
Important: Always use bacteriostatic water (BAC). Sterile technique is essential.
Most preparations come pre-mixed
If lyophilized: reconstitute with sterile or BAC water per instructions
Inspect solution - should be clear and colorless to slightly yellow
For IM/SubQ: clean injection site, draw prescribed dose
For IV: administer as slow push or dilute for infusion
Rotate injection sites
Dosing Calculator
Calculate your injection volume with visual dosing guide
To obtain 250 mcg from this solution:
Draw 0.10 mL=10 units
(1 mL = 100 units on any insulin syringe)
Draw to this mark for 250 mcg
This calculator is for research purposes only. Always verify calculations and consult protocols.
Quality Indicators
Licensed compounding pharmacy
PCAB accreditation preferred.
Reduced GSH form
Not oxidized GSSG.
Clear labeling
Concentration, lot number, expiration date.
pH affects comfort
Should be pH-adjusted to 6.0-7.0.
Unregulated sources
Risk of contamination or degradation.
What to Expect
- •Week 1-2: Minimal noticeable effects; plasma levels increase acutely
- •Week 2-4: Some notice improved energy or recovery
- •Week 4-8: Potential improvements in skin, immune resilience
- •Effects are often subtle and accumulate with consistent use
Side Effects & Safety
Side Effects
- •Generally well-tolerated when used appropriately
- •Injection site pain if pH not properly balanced
- •Rare: anaphylaxis (especially IV), hepatotoxicity with high doses
- •May worsen asthma symptoms in susceptible individuals
- •DO NOT use during chemotherapy without oncologist approval
- •Avoid during pregnancy and breastfeeding
When to Stop
- •Signs of allergic reaction
- •Severe injection site reactions
- •Asthma worsening
- •As directed by healthcare provider
References
3 StudiesHigh-dose IV Glutathione Pharmacokinetics (Aebi et al.)
Human | 2g/m² IV | Rapid clearance | t½ ~14 minutes
Classic study showing IV glutathione increases plasma levels but has short half-life.
View StudyGlutathione in Parkinson's Disease
Human | Post-mortem study | 40% reduction in substantia nigra
Established oxidative stress connection in PD pathogenesis.
View StudyIntranasal Glutathione Phase IIb Trial
Human | 45 PD patients | 3 months | Increased brain GSH levels
Mischley et al. showed intranasal GSH increased brain levels and mild motor improvement.
View StudyQuick Start Guide
Research Disclaimer
Glutathione is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving Glutathione must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of Glutathione for any purpose. Consult qualified professionals for any research applications.