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For research and educational purposes only. Not intended for human consumption.

Cerebrolysin

Well Researched
Updated Dec 2025

Neuropeptide Preparation | Neurological Recovery

Injectable
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10-50mL
Once daily
Injectable
IV: up to 10mL direct
7-30 days
Typical duration
Room
Storage

Overview

What is Cerebrolysin?

Cerebrolysin is a standardized neuropeptide preparation derived from purified porcine brain proteins, containing bioactive peptides and amino acids that exhibit neurotrophic and neuroprotective properties for stroke recovery, traumatic brain injury, and cognitive enhancement.

Key Benefits

Direct brain delivery, standardized dosing, extensive clinical evidence, ready-to-use formulation.

Mechanism of Action

IV/IM administration provides optimal bioavailability and brain penetration of neuropeptides and neurotrophic factors that mimic BDNF and NGF activity.

Molecular Information

Variable (mixture)
Weight
0
amino acids
Neuropeptide preparation
Type
Amino Acid Sequence:
Mixture of low-molecular-weight peptides and free amino acids
* Derived from purified porcine brain proteins via enzymatic proteolysis

Pharmacokinetics

Peak
30 min
Half-life
1 hr
Cleared
~5 hrs
100%50%0%0h6h12h18h24h
Peak
Half-life
Cleared
EVER Pharma data

Research Indications

Alzheimer's Disease

Meta-analyses show modest cognitive improvements, though clinical significance remains debated.

Vascular Dementia

Multiple RCTs demonstrate significant ADAS-cog and CIBIC+ improvements.

Post-Stroke Cognitive Recovery

Large meta-analysis shows significant NIHSS improvements.

Research Protocols

Disclaimer: Cerebrolysin is used clinically in over 50 countries but is not approved in the USA. These protocols are based on clinical research.

GoalDoseFrequencyRoute
Small Volume IVUp to 10mLOnce dailyUndiluted IV slow push over 3 minutes
Intramuscular (Lower Doses)Up to 5mLOnce dailyUndiluted IM injection
Acute Stroke20-50mLOnce daily for 10-21 daysIV infusion (diluted to 100mL minimum)
Traumatic Brain Injury20-50mLOnce daily for 7-30 daysIV infusion (diluted to 100mL minimum)
Alzheimer's Disease10-30mL5 days weekly for 4 weeksIV injection/infusion (2-4 cycles yearly)
Vascular Dementia10-30mL5 days weekly for 4 weeksIV injection/infusion (2-4 cycles yearly)

Timing: Start as soon as possible for acute conditions (stroke/TBI). Chronic conditions use 5-day weekly schedules. Administer in morning when possible.

Peptide Interactions

How to Reconstitute

Important: Always use bacteriostatic water (BAC). Sterile technique is essential.

1

Break ampoule and extract Cerebrolysin contents immediately before use

2

For direct injection: Up to 10mL IV undiluted (slow over 3 minutes) or up to 5mL IM

3

For infusion: Dilute 10-50mL to minimum 100mL total volume with compatible solution

4

Start infusion immediately after dilution - infuse within 15 minutes

5

Flush IV catheter with sodium chloride solution before and after administration

6

Use disposable one-way infusion sets - discard after use

Dosing Calculator

Calculate your injection volume with visual dosing guide

FINAL CONCENTRATION
2.50mg/mL
Each milliliter contains 2.50 mg of peptide
VISUAL REFERENCE (RESEARCH USE ONLY)

To obtain 250 mcg from this solution:

Draw 0.10 mL=10 units

(1 mL = 100 units on any insulin syringe)

0102030405060708090100
00.10.20.30.40.50.60.70.80.91.0
0.10 mL
10 units

Draw to this mark for 250 mcg

This calculator is for research purposes only. Always verify calculations and consult protocols.

Quality Indicators

Clear amber solution

Cerebrolysin should be clear amber colored without particles.

Room temperature storage ≤25°C

Store at room temperature per official prescribing information.

Protected from light

Stored in original carton to protect from light exposure.

Research quality considerations

Some published studies have been retracted due to research misconduct.

Frozen product

Never freeze Cerebrolysin - freezing damages peptide structure.

Mixing with incompatible solutions

Do not mix with amino acids, vitamins, or cardiovascular medications.

What to Expect

  • Week 1-2: Initial neuroprotective effects, possible mild side effects
  • Week 2-4: Neurological improvements become apparent
  • Week 4-8: Continued recovery, motor function improvements in stroke/TBI
  • Week 8-12: Sustained benefits, cognitive enhancement plateaus

Side Effects & Safety

Side Effects

  • Monitor for allergic reactions during first administration
  • Contraindicated in epilepsy and severe renal insufficiency
  • Clinical evidence shows mixed results in some studies
  • Research integrity concerns have been raised about some published studies
  • Not approved in USA but used clinically in over 50 countries
  • Use disposable one-way infusion sets

When to Stop

  • Signs of allergic reaction
  • Seizure activity
  • Severe renal issues
  • As directed by healthcare provider

References

3 Studies

TBI Systematic Review (2023)

Human | 10-50mL daily | Variable duration | GCS/GOS improvements

Analysis of 8,749 TBI patients across 10 studies confirms statistically significant improvements.

CAPTAIN II Trial (2020)

Human | 30-50mL daily | 10-28 days | Significant neurological improvement

Randomized controlled trial demonstrating efficacy and safety in moderate-severe TBI.

Subarachnoid Hemorrhage Pilot (2020)

Human | 30mL daily | 14 days | 76% vs 48% favorable outcomes

First randomized trial in SAH patients showing promising results.

Quick Start Guide

Typical Dose
20-50mL (acute) or 10-30mL (chronic)
How Often
Once daily (acute) or 5 days weekly (chronic)
Where to Inject
IV: up to 10mL direct
Timing
As soon as possible for acute conditions; morning preferred
Effects Timeline
Acute: 24-72 hours; Cognitive: 2-4 weeks; Full recovery: 4-12 weeks
Storage
Room temperature ≤25°C, protect from light, never freeze
Cycle Length
Acute: 7-30 days; Chronic: 4 weeks (2-4 cycles yearly)
Break Between
Cycles separated by 1-3 months for chronic conditions

Research Disclaimer

Cerebrolysin is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving Cerebrolysin must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of Cerebrolysin for any purpose. Consult qualified professionals for any research applications.