For research and educational purposes only. Not intended for human consumption.
5-Amino-1MQ
Limited Research- •NAD+ enhancement mechanisms confirmed
- •NNMT inhibition for metabolic health
- •Sirtuin pathway activation data
NNMT Inhibitor | Longevity & Metabolic Enhancement
Overview
What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Originally developed for metabolic research, it's gaining attention for its potential anti-aging properties and ability to improve energy metabolism at the cellular level.
Key Benefits
Enhanced NAD+ levels, improved mitochondrial function, longevity benefits, better energy metabolism, enhanced cellular repair, improved insulin sensitivity, convenient daily dosing.
Mechanism of Action
Orally administered 5-Amino-1MQ inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining higher cellular NAD+ levels throughout the body, supporting mitochondrial function and metabolic processes.
Molecular Information
Pharmacokinetics
Research Indications
NAD+ Enhancement
Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms.
Mitochondrial Function
Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress.
Cellular Repair
Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair and cellular maintenance.
Research Protocols
Disclaimer: No human clinical trials published - all dosing extrapolated from animal studies. Start with lowest effective dose to assess tolerance.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Conservative approach | 25mg | 1x daily | Oral (with food) |
| Standard starting dose | 50mg | 1x daily | Oral (with food) |
| Typical maintenance | 75mg | 1x daily | Oral (with food) |
| Maximum dose | 100mg | 1x daily | Oral (with food) |
| Split dosing option | 50mg | 2x daily | Oral (with meals) |
Timing: Take with food to improve absorption and reduce potential GI effects. Consistent daily timing helps maintain steady NAD+ levels. Morning or early afternoon dosing preferred to avoid potential sleep interference.
Peptide Interactions
How to Reconstitute
Important: Always use bacteriostatic water (BAC). Sterile technique is essential.
Use pre-made capsules for convenience and accuracy (recommended)
If using powder: measure precise dose with milligram scale
Take with food to improve absorption and reduce GI effects
Maintain consistent daily timing for optimal results
Store in cool, dry place away from light and moisture
Consider cycling: 8-12 weeks on, 2-4 weeks off
Dosing Calculator
Calculate your injection volume with visual dosing guide
To obtain 250 mcg from this solution:
Draw 0.10 mL=10 units
(1 mL = 100 units on any insulin syringe)
Draw to this mark for 250 mcg
This calculator is for research purposes only. Always verify calculations and consult protocols.
Quality Indicators
White to Off-White Capsules
High-quality capsules should be uniform in color and size with clear labeling.
Third-Party Testing Certificates
Reputable suppliers provide COA with purity analysis (>98% pure) and heavy metal testing.
Proper Pharmaceutical Packaging
Sealed bottles with moisture protection, clear expiration dates.
Moisture Damage or Clumping
Capsules should not be sticky, discolored, or show signs of moisture exposure.
Unusual Odor or Appearance
Should be relatively odorless; strong chemical odors may indicate contamination.
What to Expect
- •Week 1-2: Gradual increase in energy levels and mental clarity
- •Week 2-4: Enhanced exercise performance and recovery
- •Week 4-8: Improved metabolic markers and body composition
- •Week 8-12: Sustained longevity benefits and cellular health
- •Side effects: Generally minimal, occasional mild GI adjustment
Side Effects & Safety
Side Effects
- •No human clinical trials published - all dosing extrapolated from animal studies
- •38.4% oral bioavailability demonstrated in rats
- •Start with lowest effective dose (25-50mg) to assess tolerance
- •Take with food to reduce potential GI effects
- •Monitor for any unusual symptoms and discontinue if adverse effects occur
- •Not recommended for pregnant or breastfeeding women
- •Consult healthcare provider before use, especially with existing conditions
When to Stop
- •Significant GI discomfort
- •Unusual fatigue or weakness
- •Signs of metabolic disturbance
- •Allergic reactions
- •As directed by healthcare provider
References
3 StudiesMuscle Function in Aged Mice (2024)
Animal study | 10mg/kg/day SubQ | 8 weeks | 40% grip strength improvement
40% grip strength improvement in sedentary mice, 60% with exercise. No adverse effects observed.
Rat Pharmacokinetics Study (2021)
Animal PK study | Various doses | Bioavailability | 38.4% oral bioavailability
Demonstrated 38.4% oral bioavailability, half-life 6.9hr (oral). Supports oral administration viability.
View StudyMouse Obesity Study (2018)
Animal study | 20mg/kg TID | 11 days | n=10 mice/group | 5.1% weight loss, 30% adipocyte reduction
Diet-induced obese mice showed 5.1% weight loss, 30% adipocyte size reduction. Human equivalent ~5mg/kg/day using FDA scaling.
Quick Start Guide
Research Disclaimer
5-Amino-1MQ is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving 5-Amino-1MQ must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of 5-Amino-1MQ for any purpose. Consult qualified professionals for any research applications.