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For research and educational purposes only. Not intended for human consumption.

NA Semax Amidate

Well Researched
Updated Dec 2025

Enhanced Nootropic Peptide | Cognitive Enhancement & Neuroprotection

NasalInjectable
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600-1200μg
1-2x daily
Nasal
Intranasal spray (2-3 drops per nostril)
10-30 days
Typical duration
2-8°C
Refrigerated

Overview

What is NA Semax Amidate?

N-Acetyl Semax Amidate is an enhanced and stabilized version of the Russian nootropic peptide Semax. Through acetylation and amidation modifications, it achieves superior stability, extended half-life, and enhanced bioavailability compared to standard Semax. This synthetic ACTH (4-10) analog is designed for advanced cognitive enhancement and neuroprotection.

Key Benefits

Direct brain access via intranasal, rapid onset, enhanced cognitive effects, extended half-life, bypasses blood-brain barrier, proven efficacy in research.

Mechanism of Action

Intranasal NA Semax Amidate bypasses the blood-brain barrier via olfactory nerves, providing direct access to brain tissue with enhanced stability and prolonged activity compared to standard Semax.

Molecular Information

1,007.16 Da
Weight
7
amino acids
Modified ACTH analog
Type
Amino Acid Sequence:
Asn-Ala-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂
* N-acetylated and C-terminal amidated for enhanced bioavailability

Pharmacokinetics

Peak
30-60 minutes
Half-life
Extended vs standard Semax
Cleared
~6-12 hours
100%50%0%0h6h12h18h24h
Peak
Half-life
Cleared
Research data

Research Indications

Enhanced Focus

Rapid improvement in sustained attention, working memory within 15-30 minutes.

Memory Formation

Enhanced short and long-term memory through BDNF upregulation.

Mental Fatigue Resistance

Significant improvement in cognitive performance during fatigue.

Research Protocols

Disclaimer: Research peptide. Morning or early afternoon administration recommended to avoid sleep interference.

GoalDoseFrequencyRoute
Cognitive Enhancement600μg1x dailyIntranasal
Memory Enhancement600μg2x dailyIntranasal
Neuroprotection1200μg1x dailyIntranasal

Timing: Morning dosing optimal. Effects last 6-12 hours.

Peptide Interactions

How to Reconstitute

Important: Always use bacteriostatic water (BAC). Sterile technique is essential.

1

Calculate desired concentration

2

Add sterile saline slowly

3

Swirl gently until dissolved

4

Transfer to nasal spray bottle

5

Refrigerate

Dosing Calculator

Calculate your injection volume with visual dosing guide

FINAL CONCENTRATION
2.50mg/mL
Each milliliter contains 2.50 mg of peptide
VISUAL REFERENCE (RESEARCH USE ONLY)

To obtain 250 mcg from this solution:

Draw 0.10 mL=10 units

(1 mL = 100 units on any insulin syringe)

0102030405060708090100
00.10.20.30.40.50.60.70.80.91.0
0.10 mL
10 units

Draw to this mark for 250 mcg

This calculator is for research purposes only. Always verify calculations and consult protocols.

Quality Indicators

White fluffy powder

High-quality powder that reconstitutes clearly.

Clear solution

No particles or cloudiness after mixing.

Discolored powder

Yellow or brown indicates degradation.

What to Expect

  • 15-30 min: Initial cognitive clarity
  • 1-2 hours: Peak cognitive enhancement
  • 2-6 hours: Sustained attention benefits
  • 6-12 hours: Gradual return to baseline

Side Effects & Safety

Side Effects

  • Use sterile solutions only
  • Start with lower doses
  • Avoid if nasal congestion present
  • Not recommended during pregnancy

When to Stop

  • Persistent headaches
  • Nasal irritation
  • Mood changes
  • As directed

References

1 Studies

Default Mode Network Enhancement (2018)

Human | 24 participants | fMRI | DMN volume increase

Semax significantly increased default mode network volume in medial frontal cortex.

Quick Start Guide

Typical Dose
600-800μg
How Often
1-2x daily
Where to Inject
Intranasal (2-3 drops per nostril)
Timing
Morning or early afternoon
Effects Timeline
15-30 min onset, 6-12 hour duration
Storage
Refrigerate 2-8°C
Cycle Length
10-30 days
Break Between
Equal length break

Research Disclaimer

NA Semax Amidate is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving NA Semax Amidate must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of NA Semax Amidate for any purpose. Consult qualified professionals for any research applications.