For research and educational purposes only. Not intended for human consumption.
Melanotan II
Well Researched- •Melanocortin receptor binding mechanisms clarified
- •Sexual function enhancement pathways studied
- •Photoprotection safety profile reviewed
Synthetic Melanocortin Peptide | Tanning & Sexual Function
Overview
What is Melanotan II?
Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that stimulates melanin production for skin tanning and has additional effects on sexual arousal and appetite suppression. Originally developed at the University of Arizona as a sunless tanning agent, it has gained attention for its dual effects on pigmentation and sexual function through melanocortin receptor activation.
Key Benefits
Rapid tanning without UV exposure, enhanced libido and sexual function, appetite suppression, and improved mood through melanocortin activation.
Mechanism of Action
Binds to melanocortin receptors (MC1R, MC3R, MC4R, MC5R) throughout the body. MC1R activation stimulates melanocytes to produce eumelanin, while MC4R affects sexual arousal and appetite regulation.
Molecular Information
Pharmacokinetics
Research Indications
UV-Free Tanning
Stimulates natural melanin production for darker skin tone without sun damage.
Photoprotection
Increased melanin provides natural SPF and reduces sunburn risk.
Even Pigmentation
Promotes uniform tanning and may help with certain pigmentation disorders.
Research Protocols
Disclaimer: Melanotan II is not approved for human use. These are commonly discussed research protocols. Consult a healthcare provider before use.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Initial Loading | 0.25mg | Daily | Subcutaneous |
| Tanning Maintenance | 0.5-1mg | 2-3x weekly | Subcutaneous |
| Sexual Enhancement | 0.5-1mg | As needed | Subcutaneous |
| Minimal Side Effects | 0.1-0.25mg | Every other day | Subcutaneous |
| Photoprotection | 0.5mg | 2x weekly | Subcutaneous |
Timing: For tanning: morning dosing preferred. For sexual effects: 2-4 hours before activity. Can split daily dose to minimize side effects.
Peptide Interactions
How to Reconstitute
Important: Always use bacteriostatic water (BAC). Sterile technique is essential.
Clean vial tops with alcohol swab and let dry
Draw 2ml bacteriostatic water for 10mg vial (creates 5mg/ml concentration)
Inject water slowly down the side of peptide vial to avoid foaming
Gently roll vial between hands - do not shake vigorously
Solution should be clear to slightly yellow
Store reconstituted peptide in refrigerator wrapped in foil (light sensitive)
Draw dose with insulin syringe - typical dose is 0.05-0.2ml
Dosing Calculator
Calculate your injection volume with visual dosing guide
To obtain 250 mcg from this solution:
Draw 0.10 mL=10 units
(1 mL = 100 units on any insulin syringe)
Draw to this mark for 250 mcg
This calculator is for research purposes only. Always verify calculations and consult protocols.
Quality Indicators
White to Off-White Lyophilized Powder
Pure MT-II appears as white or slightly off-white powder before reconstitution.
Clear to Pale Yellow When Reconstituted
Properly mixed solution should be transparent with at most a slight yellow tint.
Protect From Light Exposure
MT-II is photosensitive - wrap vial in foil and minimize light exposure.
Brown or Dark Colored Powder
Indicates oxidation or impurities - do not use.
Cloudy Solution After Mixing
Suggests degradation or contamination - discard immediately.
What to Expect
- •Day 1-3: Possible nausea, flushing, and fatigue after injection
- •Day 3-7: Increased spontaneous erections (men), enhanced arousal
- •Week 1-2: Noticeable skin darkening, reduced appetite
- •Week 2-4: Significant tanning, stabilized sexual effects
- •Week 4+: Maintained tan with less frequent dosing
Side Effects & Safety
Side Effects
- •Start with very low dose (0.1-0.25mg) to assess tolerance
- •Nausea is common - can pre-treat with antiemetic if needed
- •Monitor moles and freckles for changes in size or color
- •Stay hydrated to minimize headaches and flushing
- •Avoid if history of melanoma or dysplastic nevi
- •Blood pressure may increase temporarily after injection
When to Stop
- •New or changing moles
- •Severe nausea or vomiting
- •Significant blood pressure changes
- •Allergic reactions
- •Facial flushing that doesn't resolve
- •Consult dermatologist for any skin concerns
References
3 StudiesPhotoprotection in Fair-Skinned Individuals
Human (Fitzpatrick Type I-II) | 0.1mg/kg | 3 months | Reduced sunburn incidence
Long-term study showed sustained increase in melanin production and significant reduction in UV-induced erythema in individuals with high sunburn susceptibility.
Female Sexual Arousal Disorder Trial
Human (Female) | 0.025mg/kg | Single dose | 73% reported arousal
Crossover study in premenopausal women with sexual arousal disorder showed significant increases in genital arousal and sexual desire within 24 hours.
Cardiovascular Effects Assessment
Human | Various doses | Acute monitoring | Mild BP elevation
Comprehensive cardiovascular monitoring revealed transient increases in blood pressure and heart rate, typically mild and self-limiting.
Quick Start Guide
Research Disclaimer
Melanotan II is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving Melanotan II must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of Melanotan II for any purpose. Consult qualified professionals for any research applications.