For research and educational purposes only. Not intended for human consumption.
Humanin
Well Researched- •2024-2025 Alzheimer's disease neuroprotection studies
- •HNG variant enhanced potency research
- •Mitochondrial biogenesis pathway updates
Mitochondrial-Derived Peptide | Neuroprotection & Cytoprotection
Overview
What is Humanin?
Humanin is a 24-amino-acid mitochondrial-derived peptide with broad cytoprotective effects, including neuroprotection against Alzheimer's disease and age-related cognitive decline. It primarily works through preserving mitochondrial function, inhibiting apoptosis, enhancing mitophagy and biogenesis via PGC-1α upregulation, promoting amyloid-beta phagocytosis, and suppressing inflammation. Variants like HNG show enhanced potency.
Key Benefits
Neuroprotection, anti-apoptotic effects, mitochondrial homeostasis enhancement, cognitive protection, cardioprotection, improved insulin sensitivity.
Mechanism of Action
Enhances mitochondrial biogenesis, mitophagy, electron transport chain activity, and mtDNA expression. Binds/inhibits Bax to prevent mitochondrial outer membrane permeabilization, cytochrome c release, and neuronal death. Attenuates amyloid-beta accumulation and boosts phagocytosis.
Molecular Information
Pharmacokinetics
Research Indications
Alzheimer's Disease
Attenuates amyloid-beta accumulation, boosts phagocytosis, and delays cognitive decline in mouse models.
Cognitive Protection
Higher humanin levels correlate with cognitive resilience. Low-humanin SNPs accelerate cognitive aging.
Mitochondrial Function
Preserves and enhances mitochondrial function critical for neuronal health.
Research Protocols
Disclaimer: No human clinical dosing protocols established. Research is preclinical/early-stage. Phase II trials planned for AD, metabolic syndrome, and cardiovascular disease.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Research Protocol (Mouse) | Varies by study | Twice weekly | IP or SubQ |
| HNG Analog (Research) | Enhanced potency variant | As per study design | IP or SubQ |
Timing: No established timing. Research focuses on consistent dosing schedules in animal models.
Peptide Interactions
How to Reconstitute
Important: Always use bacteriostatic water (BAC). Sterile technique is essential.
Allow vial to reach room temperature
Add appropriate sterile water or BAC water
Gently swirl to dissolve - do not shake
Solution should be clear
Store refrigerated at 2-8°C
Use within recommended timeframe per manufacturer
Dosing Calculator
Calculate your injection volume with visual dosing guide
To obtain 250 mcg from this solution:
Draw 0.10 mL=10 units
(1 mL = 100 units on any insulin syringe)
Draw to this mark for 250 mcg
This calculator is for research purposes only. Always verify calculations and consult protocols.
Quality Indicators
Limited Human Data
No human clinical trials completed. All dosing is preclinical research-based.
Strong Preclinical Evidence
Extensive research showing neuroprotective and cytoprotective effects in animal models.
Natural Compound
Endogenously produced mitochondrial peptide with physiological relevance.
Analog Variants
HNG (S14G) variant shows superior stability and potency in preclinical models.
Longevity Association
Higher levels associated with centenarian offspring and ethnic groups with lower AD risk.
What to Expect
- •No established human timeline
- •Mouse studies: Twice-weekly HNG injections improved metabolic healthspan
- •Humanin injections delayed age-related cognitive decline in mice
- •Effects may take weeks to months to manifest in animal studies
- •Human trials planned but not yet completed
Side Effects & Safety
Side Effects
- •Limited safety data - primarily preclinical research
- •No serious adverse events reported in animal studies
- •Endogenous peptide with expected physiological safety profile
- •Monitor for any unexpected effects
- •Not approved for human use
When to Stop
- •Any unexpected adverse effects
- •Signs of allergic reaction
- •As directed by research protocol
- •Consult healthcare provider
References
3 StudiesP3S Variant and APOE4 Protection (2024)
Human genetics + Mouse | Various | Resists APOE4 amyloid pathology
P3S variant enriched in Ashkenazi centenarians resists APOE4 amyloid pathology via phagocytosis enhancement.
Cognitive Aging SNP Study (2024)
Human longitudinal | Various | Low-humanin SNPs accelerate cognitive aging
Longitudinal human data showing low-humanin SNPs accelerate cognitive aging.
Lifespan Extension in C. elegans
C. elegans | Overexpression | Extended lifespan via FoxO pathway
Humanin overexpression extends lifespan in C. elegans through daf-16/FoxO-dependent mechanisms.
Quick Start Guide
Research Disclaimer
Humanin is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving Humanin must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of Humanin for any purpose. Consult qualified professionals for any research applications.