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For research and educational purposes only. Not intended for human consumption.

HGH (Somatropin)

Extensively Studied
Updated Dec 2025

Human Growth Hormone | 191aa Recombinant Growth Hormone

Injectable
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1-4 IU (0.33-1.33mg) daily
Once daily or split twice daily
Injectable
Subcutaneous: abdomen
3-6 months or ongoing
Typical duration
2-8°C
Refrigerated

Overview

What is HGH (Somatropin)?

Human Growth Hormone (HGH) is a 191 amino acid single-chain polypeptide hormone naturally produced by the anterior pituitary gland. Recombinant HGH is bioidentical to endogenous growth hormone and is FDA-approved for growth hormone deficiency in children and adults. HGH regulates growth, metabolism, body composition, and numerous physiological processes. Banned by WADA

Key Benefits

Improved body composition (increased lean mass, decreased fat mass), enhanced bone mineral density, improved lipid profile, increased exercise capacity, better quality of life and mood, enhanced recovery and healing.

Mechanism of Action

HGH binds to GH receptors on target tissues, triggering JAK2-STAT5 signaling pathway. Direct effects include lipolysis, protein synthesis stimulation, and metabolic regulation. Indirect effects occur via IGF-1 stimulation.

Molecular Information

22,124 Da (22 kDa)
Weight
191
amino acids
Single-chain polypeptide with two disulfide bridges
Type
Amino Acid Sequence:
191 amino acid single-chain protein with 4 cysteine residues forming 2 intrachain disulfide bonds
* Recombinant form (somatropin) is bioidentical to natural human growth hormone.

Pharmacokinetics

Peak
3-5 hours
Half-life
~3 hours (SubQ)
Cleared
~12-24 hours
100%50%0%0h6h12h18h24h
Peak
Half-life
Cleared
FDA prescribing information

Research Indications

Pediatric GHD

FDA-approved for children with GHD, Turner syndrome, Prader-Willi syndrome.

Adult GHD

FDA-approved for adults with GHD from childhood-onset or adult-onset causes.

HIV-Associated Wasting

FDA-approved for treatment of HIV-associated wasting.

Research Protocols

Disclaimer: HGH is FDA-approved only for specific medical conditions. Off-label use carries legal and health risks.

GoalDoseFrequencyRoute
Medical GHD Replacement0.15-0.8 mg/dayOnce dailySubcutaneous
Anti-Aging/Wellness1-2 IU/dayOnce dailySubcutaneous
Body Recomposition2-4 IU/dayOnce or twice dailySubcutaneous

Timing: Morning fasted injection maximizes fat-burning. At doses >4 IU, split into AM and PM.

Peptide Interactions

How to Reconstitute

Important: Always use bacteriostatic water (BAC). Sterile technique is essential.

1

Allow vial to reach room temp

2

Clean stoppers with alcohol

3

Inject BAC water slowly down vial wall

4

Gently swirl - never shake

5

Store refrigerated 2-8°C

Dosing Calculator

Calculate your injection volume with visual dosing guide

FINAL CONCENTRATION
2.50mg/mL
Each milliliter contains 2.50 mg of peptide
VISUAL REFERENCE (RESEARCH USE ONLY)

To obtain 250 mcg from this solution:

Draw 0.10 mL=10 units

(1 mL = 100 units on any insulin syringe)

0102030405060708090100
00.10.20.30.40.50.60.70.80.91.0
0.10 mL
10 units

Draw to this mark for 250 mcg

This calculator is for research purposes only. Always verify calculations and consult protocols.

Quality Indicators

White lyophilized powder

Should be white to off-white.

Crystal clear solution

Must be completely clear after reconstitution.

Cloudy or discolored

Indicates degradation - do not use.

What to Expect

  • Week 1-2: Improved sleep, energy, possible water retention
  • Month 1-2: Fat loss beginning, skin improvement
  • Month 3-6: Significant body composition changes

Side Effects & Safety

Side Effects

  • Water retention and joint pain
  • Carpal tunnel syndrome
  • Monitor blood glucose - causes insulin resistance
  • Contraindicated with active cancer

When to Stop

  • Signs of acromegaly
  • Severe carpal tunnel
  • Uncontrolled blood glucose
  • Any cancer diagnosis

References

1 Studies

KIMS Long-Term Safety Study (2022)

Human | 15,809 patients | 5.3 years follow-up

Cancer incidence comparable to general population.

View Study

Quick Start Guide

Typical Dose
Start 1-2 IU daily
How Often
Once daily or split AM/PM
Where to Inject
Abdomen
Timing
Morning fasted for fat loss
Effects Timeline
1-2 weeks: sleep/energy; 4-8 weeks: fat loss begins; 3-6 months: full benefits
Storage
Refrigerate 2-8°C, use within 14-28 days
Cycle Length
3-6 months minimum
Break Between
Some cycle 5 on/2 off; medical replacement is continuous

Research Disclaimer

HGH (Somatropin) is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving HGH (Somatropin) must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of HGH (Somatropin) for any purpose. Consult qualified professionals for any research applications.