For research and educational purposes only. Not intended for human consumption.
Hexarelin
Well Researched- •Most potent GHRP confirmed
- •CD36 cardioprotection mechanism detailed
- •Desensitization cycling protocols updated
Hexapeptide GHRP | Growth Hormone Release & Cardioprotection
Overview
What is Hexarelin?
Hexarelin (also known as Examorelin) is a synthetic hexapeptide growth hormone releasing peptide (GHRP) and one of the most potent GH secretagogues studied. It stimulates growth hormone release through the ghrelin receptor (GHS-R1a) and uniquely binds to cardiac CD36 receptors, providing cardioprotective effects independent of GH release. Banned by WADA
Key Benefits
Most potent GHRP for GH release, unique cardioprotective effects via CD36 receptor, supports tissue repair and recovery, neuroprotective properties.
Mechanism of Action
Binds to ghrelin receptor (GHS-R1a) on pituitary somatotrophs to stimulate pulsatile GH release. Also activates cardiac CD36 receptors providing GH-independent cardioprotection through anti-apoptotic and anti-fibrotic mechanisms.
Molecular Information
Pharmacokinetics
Research Indications
Growth Hormone Release
Most potent GHRP studied, stimulating dose-dependent GH release with peak levels at 30 minutes post-injection.
IGF-1 Elevation
Increases insulin-like growth factor 1 through enhanced pituitary GH secretion.
Pulsatile GH Pattern
Preserves natural GH secretion rhythm when dosed appropriately throughout the day.
Research Protocols
Disclaimer: Hexarelin is the most potent GHRP but causes faster desensitization than Ipamorelin. Strict cycling (8-16 weeks on, 4-6 weeks off) is essential.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| GH Optimization | 100mcg | 3x daily (morning, midday, evening) | SubQ |
| Cardioprotection Research | 100-200mcg | 2x daily | SubQ |
| Recovery/Anti-Aging | 100mcg | 2x daily (morning and bedtime) | SubQ |
| With GHRH (Synergistic) | 100mcg hexarelin + 100mcg CJC-1295 | 2-3x daily | SubQ |
Timing: Administer on empty stomach (2+ hours after eating, 30+ minutes before eating) for optimal GH release. Evening dose 30 minutes before bed maximizes nocturnal GH pulse.
Peptide Interactions
How to Reconstitute
Important: Always use bacteriostatic water (BAC). Sterile technique is essential.
Clean both vial tops with alcohol and let dry completely
For 2mg vial: Add 2mL bacteriostatic water (creates 100mcg per 10 units)
For 5mg vial: Add 2.5mL bacteriostatic water (creates 200mcg per 10 units)
Inject water slowly down the side of the vial to prevent foaming
Gently swirl or roll vial - do not shake vigorously
Solution should be clear and colorless
Label with reconstitution date and concentration
Store immediately in refrigerator at 2-8°C
Dosing Calculator
Calculate your injection volume with visual dosing guide
To obtain 250 mcg from this solution:
Draw 0.10 mL=10 units
(1 mL = 100 units on any insulin syringe)
Draw to this mark for 250 mcg
This calculator is for research purposes only. Always verify calculations and consult protocols.
Quality Indicators
Third-party COA verification
Purchase from vendors providing certificates showing >98% purity and correct molecular weight (887 Da).
Proper cold chain shipping
Peptide should arrive with ice packs in insulated packaging.
Vacuum-sealed vials
Legitimate products create vacuum when reconstituted.
Monitor for desensitization
GH response decreases over time - follow cycling protocols strictly.
Cortisol and prolactin effects
Unlike Ipamorelin, hexarelin can elevate cortisol and prolactin.
Pre-mixed solutions
Avoid pre-reconstituted products - hexarelin degrades rapidly in solution.
What to Expect
- •Day 1-7: Improved sleep quality, potential facial flushing post-injection
- •Week 2-4: Enhanced recovery from exercise, improved skin quality
- •Week 4-8: Noticeable improvements in lean mass and fat loss, some desensitization may begin
- •Week 8-12: Continued benefits but GH response reduced 40-50% from baseline
- •Week 12-16: Maximum cycle length - take mandatory 4-6 week break
Side Effects & Safety
Side Effects
- •Most potent GHRP but also highest side effect profile among GHRPs
- •Elevates cortisol and prolactin at standard doses - unlike Ipamorelin
- •May cause water retention, particularly in first 1-2 weeks
- •Can affect glucose metabolism - monitor if diabetic or pre-diabetic
- •Not recommended for those with active cancer due to growth-promoting effects
- •WADA prohibited substance - banned in competitive sports
When to Stop
- •Signs of desensitization
- •Significant cortisol/prolactin elevation
- •Glucose metabolism issues
- •Water retention concerns
- •As directed by healthcare provider
References
3 StudiesGrowth Hormone-Releasing Activity (1994)
Human | 0.5-2 μg/kg IV | Single dose | Dose-dependent GH release
Double-blind study demonstrating dose-dependent GH release. Peak plasma GH at 30 minutes.
View StudyMyocardial Function After MI (2018)
Mouse | 0.3 mg/kg/day SubQ | 21 days | Improved LV function, reduced fibrosis
Hexarelin treatment reduced LV collagen concentration by ~53%, decreased inflammatory cytokines.
ALS Neuroblastoma Model Protection (2023)
In vitro | 1 μM | Human neuroblastoma cells | Neuroprotective effects
Hexarelin protected cells from H2O2-induced cytotoxicity by increasing Bcl-2 expression.
Quick Start Guide
Research Disclaimer
Hexarelin is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving Hexarelin must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of Hexarelin for any purpose. Consult qualified professionals for any research applications.