For research and educational purposes only. Not intended for human consumption.
GHK-Cu
Well Researched- •Gene expression: affects 31.2% of human genes
- •Plasma levels: ~200ng/ml at 20 → ~80ng/ml at 60
- •Wound healing and tissue regeneration research updates
Copper Peptide | Skin Regeneration & Anti-Aging Compound
Overview
What is GHK-Cu?
GHK-Cu is a naturally occurring copper tripeptide found in human plasma, saliva, and urine. Plasma levels decline from ~200 ng/ml at age 20 to ~80 ng/ml by age 60. Research shows it affects 31.2% of human genes and promotes wound healing, collagen synthesis, and anti-aging effects at the cellular level. Injectable GHK-Cu provides systemic distribution for tissue regeneration research.
Key Benefits
Enhanced collagen production, accelerated wound healing, tissue regeneration, anti-inflammatory effects, hair follicle stimulation, systemic anti-aging research applications.
Mechanism of Action
Injectable GHK-Cu provides systemic copper peptide delivery. Activates fibroblasts, stimulates collagen and elastin synthesis, promotes angiogenesis, modulates over 4,000 genes including those involved in DNA repair, antioxidant responses, and stem cell activity.
Molecular Information
Pharmacokinetics
Research Indications
Collagen Synthesis (9-fold increase)
Rat wound studies show subcutaneous GHK-Cu increases total protein and collagen synthesis vs. saline placebo. 9-fold increase in collagen synthesis observed in healthy rats. Stimulates type I and III collagen production.
Angiogenesis & Blood Vessel Growth
Promotes VEGF and bFGF expression for new blood vessel formation. Rabbit wound models showed improved blood vessel growth, granular tissue formation, and antioxidant enzyme activity with GHK-Cu injections.
Extracellular Matrix Remodeling
Enhances ECM production, modulates metalloproteinases and TIMP-1/2 for optimal collagen/glycosaminoglycan turnover. Accelerates wound contraction and epithelialization in wound chamber studies.
Diabetic Wound Healing
Diabetic rat models healed faster with GHK-Cu, showing higher glutathione, ascorbic acid levels, enhanced fibroblast/mast cell activation, and improved epithelialization rates.
Ischemic Wound Recovery
Ischemic rat wounds treated with GHK-Cu showed faster healing, reduced MMP-2/MMP-9 metalloproteinases, and lower TNF-β inflammatory levels.
Research Protocols
Disclaimer: These are commonly discussed research protocols and not medical advice. Consult a healthcare provider before use.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Tissue regeneration | 1-2 mg | 1x daily | Subcutaneous |
| Wound healing | 2-4 mg | 1x daily | Subcutaneous near site |
| Anti-aging research | 1-2 mg | 1x daily | Subcutaneous |
| Hair follicle research | 1-2 mg | 1x daily | Subcutaneous (scalp area) |
| Systemic collagen support | 2-3 mg | 1x daily | Subcutaneous |
Timing: Inject GHK-Cu subcutaneously, preferably in the morning or near target tissue for localized effects. Due to short half-life (1-2 hrs), daily dosing is typical. Reconstitute with bacteriostatic water.
Peptide Interactions
How to Reconstitute
Important: Always use bacteriostatic water (BAC). Sterile technique is essential.
Clean work area and hands thoroughly
Calculate required BAC water volume using calculator below
Draw BAC water into syringe
Inject slowly down vial side (not directly onto powder)
Gently swirl until dissolved (never shake)
Store in refrigerator, use within 28 days
Dosing Calculator
Calculate your injection volume with visual dosing guide
To obtain 250 mcg from this solution:
Draw 0.10 mL=10 units
(1 mL = 100 units on any insulin syringe)
Draw to this mark for 250 mcg
This calculator is for research purposes only. Always verify calculations and consult protocols.
Quality Indicators
White, Fluffy Cake
Lyophilized powder should appear as a white, fluffy 'cake' that fills most of the vial bottom. This indicates proper freeze-drying.
Light Blue Solution
When properly mixed with BAC water, solution should have a light blue tint from copper content.
Slight Clumping
Small clumps that dissolve completely with gentle swirling are acceptable. Shipping can cause minor compaction.
Collapsed or Melted Appearance
If powder appears collapsed, melted, or stuck to vial sides, it may have been exposed to heat during shipping.
Cloudy After Reconstitution
Persistent cloudiness, particles, or precipitates after gentle mixing indicate degraded or contaminated peptide.
What to Expect
- •Week 1-2: Initial tissue response, reduced inflammation at injection sites
- •Week 2-4: Enhanced wound healing, improved tissue repair processes
- •Week 4-8: Visible tissue regeneration, collagen remodeling begins
- •Week 8-12: Significant tissue improvement, musculoskeletal repair benefits
- •Hair growth (scalp injections): 6-12 weeks for initial results
- •Most effective for: Wound healing, tissue regeneration, musculoskeletal repair, anti-aging
Side Effects & Safety
Side Effects
- •Injection site reactions: mild redness, swelling, or bruising (common, resolves in 24-48 hrs)
- •Characteristic light blue coloration at injection site from copper content
- •Mild warmth or tingling at injection area (normal, indicates absorption)
- •Rare: headache, nausea, or fatigue in first few days (usually temporary)
- •Very rare: allergic reaction - discontinue if hives, difficulty breathing, or severe swelling occur
When to Stop
- •Signs of infection at injection site (increasing redness, pus, fever)
- •Severe allergic reaction (anaphylaxis symptoms)
- •Unusual systemic effects lasting more than 48 hours
- •Persistent pain or swelling beyond normal healing time
- •Consult healthcare provider before starting or if concerns arise
References
17 StudiesGHK-Cu Promotes Mucosal Healing in Ulcerative Colitis
Animal Model | Frontiers in Pharmacology | 2025 | Systemic GHK-Cu | IBD
Systemic GHK-Cu administration promoted mucosal healing in DSS-induced ulcerative colitis by enhancing tight junction proteins (ZO-1, Occludin), increasing goblet cells, and suppressing TNF-α/IL-6/IL-1β via SIRT1/STAT3 pathway.
View StudyIntranasal GHK-Cu Delays Cognitive Impairment in Alzheimer's Model
Animal Model | PMC10690187 | 2023 | 5xFAD Mice | Neuroprotection
8-12 weeks intranasal GHK-Cu in transgenic AD mice reduced amyloid plaques in frontal cortex and hippocampus, lowered MCP-1 neuroinflammation markers, and delayed cognitive impairment approaching non-transgenic control levels.
View StudyGHK-Cu/CaT-ME Accelerates Hair Regrowth via Wnt/β-Catenin
Animal Model | PMC10643103 | 2023 | Hair Cycle Study
GHK-Cu in ionic liquid microemulsion demonstrated faster hair regrowth (6 days vs 8-9 days control) by activating Wnt/β-Catenin pathway, optimizing microcirculation, and stimulating growth factors.
View StudyQuick Start Guide
Research Disclaimer
GHK-Cu is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving GHK-Cu must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of GHK-Cu for any purpose. Consult qualified professionals for any research applications.