For research and educational purposes only. Not intended for human consumption.
DSIP
Limited Research- •Sleep architecture and slow-wave sleep studies
- •HPA axis modulation research updates
- •Stress resilience and cortisol regulation data
Delta Sleep-Inducing Peptide | Sleep & Stress Modulator
Overview
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide discovered in 1974 in rabbit brain. Originally isolated for its sleep-promoting properties, DSIP has diverse neuromodulatory effects including stress reduction, pain modulation, and endocrine regulation.
Key Benefits
Enhanced sleep quality through slow-wave sleep promotion, stress reduction via cortisol modulation, potential pain relief, and mood stabilization without traditional sedative effects.
Mechanism of Action
Modulates multiple neurotransmitter systems including GABA enhancement, NMDA receptor interaction, and endogenous opioid system modulation. Also regulates hypothalamic-pituitary-adrenal axis.
Molecular Information
Pharmacokinetics
Research Indications
Deep Sleep Enhancement
Promotes delta wave sleep, the most restorative sleep phase for physical recovery.
Sleep Efficiency
Reduces sleep latency and nocturnal awakenings without morning grogginess.
Natural Sleep Architecture
Supports natural sleep cycles rather than forcing sedation.
Research Protocols
Disclaimer: DSIP has limited human clinical data. These protocols are based on available research and anecdotal reports. Consult a healthcare provider before use.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Sleep Enhancement | 100-200mcg | Once nightly | Subcutaneous |
| Chronic Pain | 250-300mcg | Daily | IV or SubQ |
| Stress Management | 150mcg | Evening | Subcutaneous |
| Withdrawal Support | 200-300mcg | Twice daily | IV preferred |
| Athletic Recovery | 100-150mcg | Post-training | Subcutaneous |
Timing: Best taken 30-60 minutes before intended bedtime. Some prefer earlier evening dosing (2-3 hours before bed) for gradual onset.
Peptide Interactions
How to Reconstitute
Important: Always use bacteriostatic water (BAC). Sterile technique is essential.
Clean vial tops with alcohol swab and let dry completely
For 1mg vial, add 1ml BAC water (creates 1mg/ml or 1000mcg/ml)
Inject water slowly down vial side to prevent foaming
Gently roll between palms - do not shake
Solution should be clear and colorless
For 100mcg dose, draw 0.1ml (10 units on insulin syringe)
Store reconstituted peptide in refrigerator immediately
Dosing Calculator
Calculate your injection volume with visual dosing guide
To obtain 250 mcg from this solution:
Draw 0.10 mL=10 units
(1 mL = 100 units on any insulin syringe)
Draw to this mark for 250 mcg
This calculator is for research purposes only. Always verify calculations and consult protocols.
Quality Indicators
White lyophilized powder
Pure DSIP appears as white to off-white powder before reconstitution.
Clear solution when mixed
Properly reconstituted DSIP should be completely clear and colorless.
Short stability period
DSIP has limited stability - use reconstituted solution within 14 days.
Protect from degradation
DSIP degrades quickly - minimize light exposure and temperature fluctuations.
Yellow or cloudy solution
Indicates degradation or contamination - do not use.
What to Expect
- •First dose: Noticeable sleep pressure and easier sleep onset
- •Night 1-3: Deeper sleep, fewer awakenings, vivid dreams possible
- •Day 2-5: Improved morning refreshment, stable daytime energy
- •Day 5-10: Cumulative stress reduction, mood improvements
- •Post-cycle: Benefits may persist 1-2 weeks after stopping
Side Effects & Safety
Side Effects
- •Generally well-tolerated with minimal side effects
- •Some users report mild drowsiness or dizziness initially
- •Occasional reports of headaches in sensitive individuals
- •No tolerance or dependence reported in studies
- •Avoid driving until effects are known
- •Not recommended during pregnancy or breastfeeding
When to Stop
- •Excessive drowsiness
- •Persistent dizziness
- •Severe headaches
- •Any adverse reactions
- •As directed by healthcare provider
References
3 StudiesStroke Recovery in Rats (2021)
Rats | 120 μg/kg nasal | 7 days | Enhanced motor recovery
Intranasal DSIP administration before and after induced stroke accelerated motor function recovery.
Chronic Insomnia Study (1991)
Human | 15-30 nmol | 6 consecutive nights | Improved sleep efficiency
Double-blind crossover study showed DSIP improved objective sleep quality with higher sleep efficiency and shorter sleep latency.
Endocrine Modulation Research (1988)
Human/Animal | Various doses | Multiple studies | Hormone regulation
Multiple studies demonstrated DSIP modulates ACTH, cortisol, and growth hormone release.
Quick Start Guide
Research Disclaimer
DSIP is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving DSIP must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of DSIP for any purpose. Consult qualified professionals for any research applications.