For research and educational purposes only. Not intended for human consumption.
Cyclic Glycine-Proline
Limited Research- •42% amyloid plaque reduction (mouse)
- •IGF-1 bioavailability regulation
- •Crosses blood-brain barrier
cGP | IGF-1 Bioavailability Regulator & Neuroprotective Peptide
Overview
What is Cyclic Glycine-Proline?
Cyclic glycine-proline (cGP) is a naturally occurring cyclic dipeptide found in human plasma, breast milk, and CSF. It is a metabolite of IGF-1 that regulates IGF-1 bioavailability. Research suggests neuroprotective, nootropic, and cardioprotective properties with clinical trials showing benefits for cognitive function and stroke recovery.
Key Benefits
Neuroprotection, cognitive enhancement, IGF-1 optimization, cardiovascular support, convenient oral administration, crosses blood-brain barrier, endogenous to the body.
Mechanism of Action
cGP competes with IGF-1 for binding to IGFBP-3, regulating bioavailable IGF-1. Also acts as positive allosteric modulator of AMPA and GABA-A receptors and increases BDNF levels.
Molecular Information
Pharmacokinetics
Research Indications
Cognitive Enhancement
Higher cGP correlates with better memory retention in elderly.
Neuroprotection
Protects neural stem cells via Akt/MDM2-p53 pathway.
Alzheimer's Disease
42% reduction in amyloid plaque load in mouse models.
Research Protocols
Disclaimer: cGP is an endogenous compound. Can be used long-term.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Cognitive Support | 20-40μg | 1x daily | Oral |
| Neuroprotection | 40-50μg | 1x daily | Oral |
| Via Blackcurrant Extract | 300mg BCA | 2x daily | Oral |
Timing: Take consistently at the same time daily.
Peptide Interactions
How to Reconstitute
Important: Always use bacteriostatic water (BAC). Sterile technique is essential.
Available as capsules or blackcurrant-derived supplements
Take with water
Maintain consistent daily timing
Store in cool, dry place
Dosing Calculator
Calculate your injection volume with visual dosing guide
To obtain 250 mcg from this solution:
Draw 0.10 mL=10 units
(1 mL = 100 units on any insulin syringe)
Draw to this mark for 250 mcg
This calculator is for research purposes only. Always verify calculations and consult protocols.
Quality Indicators
Third-party tested
Independent purity testing.
Clear concentration labeling
States cGP content per serving.
Blackcurrant-derived
NZ blackcurrant extracts are well-researched.
What to Expect
- •Week 1-2: Subtle mental clarity
- •Week 2-4: Enhanced cognitive function
- •Week 4-8: Neuroprotective benefits accumulating
- •Week 8-12: Optimal IGF-1 regulation
Side Effects & Safety
Side Effects
- •Endogenous compound - generally well-tolerated
- •No significant adverse events in research
- •Start with lower dose to assess response
- •Limited long-term human data
When to Stop
- •Adverse effects
- •As directed by healthcare provider
References
2 StudiesAlzheimer's Mouse Model (2023)
Mouse | 28 days | 42% plaque reduction
Improved spatial memory and reduced amyloid plaque density.
Parkinson's Clinical Study (2018)
Human | 11 patients | 28 days | 74% CSF cGP increase
Reduced anxiety/depression scores with blackcurrant supplementation.
Quick Start Guide
Research Disclaimer
Cyclic Glycine-Proline is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving Cyclic Glycine-Proline must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of Cyclic Glycine-Proline for any purpose. Consult qualified professionals for any research applications.