Muscle & Performance

5-Amino-1MQ is a selective, membrane-permeable small-molecule NNMT inhibitor (EC50 ~2.3 µM in adipocytes) that blocks nicotinamide methylation to 1-MNA, preserving nicotinamide for NAD+ salvage, elevating NAD+ 1.2-1.6 fold, and activating Sirt1 for metabolic benefits including ~35% adipose reduction without appetite effects.

TB-500 is a synthetic 7-amino-acid fragment (Ac-LKKTETQ) from thymosin beta-4's actin-binding site that promotes tissue repair through G-actin sequestration, ROCK1 downregulation, cell migration, progenitor cell mobilization, angiogenesis, and anti-inflammatory effects. Phase 2 human trials show 61% improvement in wound reepithelialization by day 7.

Follistatin-344 is a glycoprotein that competitively blocks myostatin's ActRIIB binding, interrupting SMAD2/3 signaling to enable muscle growth. AAV1-FS-344 gene therapy in mdx mice produced 15-fold serum follistatin increase, significant muscle mass/strength gains sustained 560+ days without cardiac or reproductive adverse effects.

IGF-1 LR3 is a synthetic 83-amino-acid IGF-1 analog with an Arg3 substitution and 13-aa N-terminal extension that reduces IGFBP binding, extending half-life from ~15 min to 20-30 hours. Activates PI3K/Akt/mTOR pathway for protein synthesis while suppressing FoxO-mediated ubiquitin-proteasome degradation via GSK3β inhibition.