Cognitive & Neuro

Humanin is a 24-amino acid mitochondrial-derived peptide originally discovered in surviving neurons of Alzheimer's disease patients. It exerts neuroprotective effects primarily by inhibiting apoptosis via BAX binding, mitigating oxidative stress, preserving mitochondrial function, and counteracting neurotoxic insults like amyloid-beta in multiple disease models.

Dihexa is a synthetic oligopeptide derived from angiotensin IV that acts as an HGF mimetic, binding hepatocyte growth factor with high affinity and enhancing c-Met receptor signaling to promote synaptogenesis 7-fold greater than BDNF, neurogenesis, and memory restoration in preclinical Alzheimer's models.

NA Semax Amidate is an enhanced, stabilized version of Semax with superior bioavailability and extended half-life for advanced cognitive enhancement and neuroprotection.

Omberacetam is a synthetic nootropic dipeptide 1000x more potent than piracetam, enhancing memory, learning, and neuroprotection through BDNF/NGF upregulation.

PT-141 (bremelanotide/Vyleesi) is the first FDA-approved treatment targeting neurological sexual desire via MC4R agonism in hypothalamic/limbic regions. Approved 2019 for premenopausal HSDD at 1.75 mg SC, RECONNECT trials showed ~1 additional satisfying sexual event per 2 months vs placebo.

Selank is a synthetic heptapeptide analog of tuftsin with additional glyproline residues, developed in Russia and investigated for anxiolytic, nootropic, neuroprotective, and immunomodulatory effects through GABAergic and neurotransmitter system modulation.

Semax is a synthetic heptapeptide analog of ACTH(4-10) that enhances BDNF and NGF expression, modulates dopaminergic, serotonergic, and cholinergic systems, and demonstrates neuroprotective effects through inhibition of nitric oxide synthesis, improved cerebral blood flow, and anti-inflammatory gene modulation in stroke research.

VIP is a 28-amino acid neuropeptide with potent vasodilatory, immunomodulatory, and neuroprotective properties. FDA breakthrough therapy designation for ARDS/COVID-19 respiratory failure.

Adalank is an enhanced Selank derivative with acetylation and amidation for superior stability, researched for anxiety reduction, cognitive enhancement, and stress resilience without dependency.

Adamax is an enhanced Semax derivative with adamantane modification for superior BBB penetration, researched for cognitive enhancement, neuroprotection, and neuroplasticity.

Cyclic glycine-proline is an endogenous cyclic dipeptide that regulates IGF-1 bioavailability and shows neuroprotective and cognitive benefits in research.

P21 is a CNTF-derived tetrapeptide that enhances neurogenesis and cognitive function by activating CNTF receptor pathways without the side effects of full-length CNTF.

PE-22-28 is a synthetic peptide derived from sortilin propeptide that acts as a TREK-1 potassium channel blocker, showing rapid antidepressant effects in preclinical models.

Pinealon is a synthetic tripeptide (EDR) derived from pineal gland research that shows neuroprotective effects and may support cognitive function and circadian rhythm regulation.