For research and educational purposes only. Not intended for human consumption.
AHK-Cu
Well Researched- •Hair follicle elongation stimulation data
- •VEGF production enhancement confirmed
- •TGF-β1 inhibition mechanism detailed
Hair Growth Copper Peptide | Dermal Papilla Stimulator
Overview
What is AHK-Cu?
AHK-Cu (Copper Tripeptide-3) is a synthetic copper-binding tripeptide composed of Alanine-Histidine-Lysine complexed with a copper ion. While structurally similar to GHK-Cu (differing only in the first amino acid), AHK-Cu demonstrates targeted activity on dermal papilla cells and hair follicles. Research shows it stimulates hair follicle elongation, promotes dermal papilla cell proliferation, increases VEGF production, and inhibits TGF-β1.
Key Benefits
Stimulates hair follicle elongation, promotes dermal papilla cell proliferation, increases VEGF for improved scalp circulation, reduces TGF-β1 (counters DHT effects), supports collagen synthesis.
Mechanism of Action
AHK-Cu penetrates the scalp to deliver copper directly to dermal papilla cells and hair follicles. It activates proliferation pathways, elevates the Bcl-2/Bax ratio (anti-apoptotic), increases VEGF production for enhanced blood flow, and reduces TGF-β1 secretion.
Molecular Information
Pharmacokinetics
Research Indications
Hair Follicle Elongation
Ex vivo studies demonstrate stimulation of human hair follicle elongation at concentrations as low as 10⁻¹² M.
Dermal Papilla Cell Proliferation
Increases proliferation of key regulatory cells for hair follicle cycling.
VEGF Upregulation
Boosts vascular endothelial growth factor production for improved follicle nutrition.
Research Protocols
Disclaimer: AHK-Cu is primarily used topically. Injectable use has limited research. Best results require consistent use for 3-6+ months.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Hair Growth - Scalp | 0.5-1% solution | 1-2x daily | Topical |
| Combined Protocol | 0.3-0.5% with minoxidil | 1-2x daily | Topical |
| Skin Regeneration | 0.3-1% serum | 1-2x daily | Topical |
Timing: Evening application preferred to avoid UV exposure which can degrade the peptide.
Peptide Interactions
How to Reconstitute
Important: Always use bacteriostatic water (BAC). Sterile technique is essential.
Dissolve AHK-Cu powder in distilled water or formulation base
Verify pH is between 5.5-7.0
Add to cool-down phase of formulation (<40°C)
Mix gently until fully incorporated
Transfer to dark glass container
Store refrigerated at 2-8°C
Use within 30 days of preparation
Dosing Calculator
Calculate your injection volume with visual dosing guide
To obtain 250 mcg from this solution:
Draw 0.10 mL=10 units
(1 mL = 100 units on any insulin syringe)
Draw to this mark for 250 mcg
This calculator is for research purposes only. Always verify calculations and consult protocols.
Quality Indicators
Light blue powder
Characteristic color from the copper complex.
99%+ purity with COA
Certificate of analysis confirming identity and purity.
pH sensitive
Final product pH should be 5.5-7.0 for stability.
Discolored solution
Brown, green, or colorless indicates degradation.
What to Expect
- •Week 1-2: No visible changes; peptide working at cellular level
- •Week 2-4: Some report reduced hair shedding
- •Month 1-2: Fine vellus hairs may begin appearing
- •Month 2-3: New growth becoming visible; existing hairs may appear thicker
- •Month 4-6: Significant results visible with consistent use
- •Month 6-12: Full results achieved
Side Effects & Safety
Side Effects
- •Generally well-tolerated topically
- •Avoid with acidic products (AHAs, BHAs, Vitamin C) - use at different times
- •Do not combine with copper supplements
- •Keep pH between 5.5-7.0 for stability
- •Store properly - degrades with heat and light
- •Patch test if sensitive skin
When to Stop
- •Persistent irritation or redness
- •Allergic reaction signs
- •Skin infection develops
- •As directed by healthcare provider
References
2 StudiesIonic Liquid Microemulsions for Topical Peptide Delivery (2023)
Formulation study | Enhanced delivery systems | Improved topical delivery and stability
Novel delivery system using ionic liquid microemulsions for enhanced copper tripeptide effects.
Human Skin Penetration of Copper Tripeptide
In vitro | Human skin samples | Layer-by-layer analysis
Demonstrated penetration through skin layers for therapeutic applications.
Quick Start Guide
Research Disclaimer
AHK-Cu is sold for laboratory research purposes only and is not intended for human or animal consumption. The information provided on this page is compiled from published research, veterinary studies, and anecdotal reports for educational purposes. This content does not constitute medical advice, diagnosis, or treatment recommendations. Any research involving AHK-Cu must comply with all applicable local, state, and federal regulations. BioInfinity Lab makes no claims regarding the safety or efficacy of AHK-Cu for any purpose. Consult qualified professionals for any research applications.