Why GHK-Cu is the foundational copper-peptide research compound
GHK-Cu was first identified by Loren Pickart in 1973 as a small bioactive peptide-copper complex isolated from human plasma. The compound's age (50+ years of research literature) and unusual mechanism — a tripeptide that binds copper(II) at physiologically relevant affinity and modulates copper-dependent enzymes — makes it one of the most-cited research peptides in dermal-research and tissue-repair literature.